Chemical Biology · Drug Discovery · Biophysics

Angela
Develin.

Post Doctoral Fellow at Boehringer Ingelheim, specializing in biophysical characterization of therapeutic antibodies and high-throughput developability screening.

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Angela Develin

01About

Biophysical researcher with over a decade of experience spanning clinical pharmacy, bioanalytical chemistry, and drug discovery. I work on biophysical characterization of therapeutic antibodies and developability screening for high-concentration liquid formulations at Boehringer Ingelheim.

My Ph.D. at Virginia Commonwealth University focused on fragment-based drug design and protein-ligand biophysics — understanding how molecules behave and interact at the atomic level. Before grad school, I worked as a bioanalytical chemist at PPD and spent five years as a pharmacy technician — experiences that shaped how I think about the journey from bench to patient.

NMR Spectroscopy Fragment-based Drug Design Biophysical Chemistry Protein Purification LC-MS/MS HPLC FPLC Binding Assays Isothermal Titration Calorimetry Fluorescence Spectroscopy Protein Crystallization Protein Expression Protein-Membrane Interactions Size Exclusion Cell Culture Proteomics Small Molecules Drug Development Ligand Binding Method Development GraphPad Prism Data Analysis

02Experience

Sep 2024 — Present Ridgefield, CT

Post Doctoral Fellow

Boehringer Ingelheim

Researcher in the Biophysical Characterization group within Biotherapeutics Discovery. Developing and optimizing high-throughput screening methodologies to assess therapeutic antibody behavior in high-concentration liquid formulations, supporting identification of candidates suitable for subcutaneous delivery. Evaluating key biophysical properties including self-association, aggregation propensity, and colloidal stability to identify developability liabilities early in the discovery pipeline.

Aug 2019 — Aug 2024 Richmond, VA

Chemical Biology Ph.D.

Virginia Commonwealth University

Doctoral research in fragment-based drug design and biophysical characterization of protein-ligand interactions. Originating member of the Fuglestad Lab. Led investigations into binding thermodynamics and structural determinants of molecular recognition, targeting proteins historically considered undruggable. Employed 2D and 3D NMR spectroscopy to detect weak binding interactions, achieving a 75-fold improvement in lead fragment binding affinity.

Jan 2019 — Jul 2019 Richmond, VA

Assistant Scientist

PPD

Bioanalytical Chemist in the Chromatographic Science department. Quantified drug and metabolite concentrations in clinical trial patient samples using LC-MS/MS, supporting pharmacokinetic analyses across multiple therapeutic programs in a regulated GLP environment.

Sep 2014 — Jan 2019

Certified Pharmacy Technician

CVS Health

Five years in retail pharmacy handling insurance claims, patient consultations, and prescription management — building the foundation for understanding the full drug development lifecycle from bench to patient.

03Education

Ph.D.

Chemical Biology

Virginia Commonwealth University

2019 — 2024

B.S.

Chemistry

Virginia Commonwealth University

2018

04Research Focus

Antibody Characterization

High-throughput biophysical screening of therapeutic antibodies for developability, assessing self-association, aggregation, and colloidal stability in concentrated formulations.

Fragment-Based Drug Design

Identifying low-affinity chemical starting points against undruggable targets using NMR spectroscopy, with iterative optimization to improve binding affinity.

Protein-Ligand Biophysics

Characterizing binding thermodynamics and molecular recognition through 2D/3D NMR, mapping fragment binding sites at residue-level resolution.

05Publications

Biochemistry

Inositol Hexaphosphate as an Inhibitor and Potential Regulator of p47phox Membrane Anchoring

Protein Science

Investigating protein-membrane interactions using native reverse micelles constructed from naturally sourced lipids

FASEB Journal

Alternative Approach to NADPH Oxidase Inhibition: Challenging Selectivity through Fragment Based Drug Design

Langmuir

Membrane-Mimicking Reverse Micelles for High-Resolution Interfacial Study of Proteins and Membranes

06Mentorship

Project SEED · Graduate Mentor

American Chemical Society · Summer 2022

Mentored a local high school student from an underprivileged area through a hands-on summer research experience in protein-lipid interactions. Worked side-by-side teaching basic and complex laboratory techniques, culminating in a poster presentation of the student's independent research.

07 · What's Next?

Let's Connect

I'm always interested in discussing drug discovery, biophysical research, or potential collaborations.

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